We thank the National Basic Research Program of China (973 Program 2010CB833300) and the NSFC (20923005, 20932008, 21025209, and 21121062) for financial support. We also thank Prof. Dr. G. Helmchen of Univ. Heidelberg for generously offering dbcot.
Asymmetric N-Allylation of Indoles Through the Iridium-Catalyzed Allylic Alkylation/Oxidation of Indolines†
Article first published online: 11 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 21, pages 5183–5187, May 21, 2012
How to Cite
Liu, W.-B., Zhang, X., Dai, L.-X. and You, S.-L. (2012), Asymmetric N-Allylation of Indoles Through the Iridium-Catalyzed Allylic Alkylation/Oxidation of Indolines. Angew. Chem. Int. Ed., 51: 5183–5187. doi: 10.1002/anie.201200649
- Issue published online: 15 MAY 2012
- Article first published online: 11 APR 2012
- Manuscript Received: 24 JAN 2012
- National Basic Research Program of China. Grant Number: 2010CB833300
- NSFC. Grant Numbers: 20923005, 20932008, 21025209, 21121062
- allylic substitution;
- asymmetric catalysis;
Two steps can be better than one: An efficient synthesis of enantioenriched N-allylindoles by a one-pot Ir-catalyzed asymmetric allylic alkylation/oxidation reaction of indolines has been realized. The current method features high regioselectivity and enantioselectivity together with a broad range of indoles with varying electronic properties. The utility of this method was demonstrated by the synthesis of dihydropyrrolo[1,2-a]indole derivatives.