We thank the National Basic Research Program of China (973 Program 2010CB833300) and the NSFC (20923005, 20932008, 21025209, and 21121062) for financial support. We also thank Prof. Dr. G. Helmchen of Univ. Heidelberg for generously offering dbcot.
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Communication
Asymmetric N-Allylation of Indoles Through the Iridium-Catalyzed Allylic Alkylation/Oxidation of Indolines†
Article first published online: 11 APR 2012
DOI: 10.1002/anie.201200649
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Liu, W.-B., Zhang, X., Dai, L.-X. and You, S.-L. (2012), Asymmetric N-Allylation of Indoles Through the Iridium-Catalyzed Allylic Alkylation/Oxidation of Indolines. Angew. Chem. Int. Ed., 51: 5183–5187. doi: 10.1002/anie.201200649
- †
Publication History
- Issue published online: 15 MAY 2012
- Article first published online: 11 APR 2012
- Manuscript Received: 24 JAN 2012
Funded by
- National Basic Research Program of China. Grant Number: 2010CB833300
- NSFC. Grant Numbers: 20923005, 20932008, 21025209, 21121062
Keywords:
- allylic substitution;
- asymmetric catalysis;
- indoles;
- iridium;
- oxidation
Two steps can be better than one: An efficient synthesis of enantioenriched N-allylindoles by a one-pot Ir-catalyzed asymmetric allylic alkylation/oxidation reaction of indolines has been realized. The current method features high regioselectivity and enantioselectivity together with a broad range of indoles with varying electronic properties. The utility of this method was demonstrated by the synthesis of dihydropyrrolo[1,2-a]indole derivatives.