Communication

DNA Origami Gatekeepers for Solid-State Nanopores†

  1. Ruoshan Wei1,‡,
  2. Thomas G. Martin2,‡,
  3. Ulrich Rant1,*,
  4. Hendrik Dietz2,*

Article first published online: 4 APR 2012

DOI: 10.1002/anie.201200688

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 20, pages 4864–4867, May 14, 2012

Additional Information

How to Cite

Wei, R., Martin, T. G., Rant, U. and Dietz, H. (2012), DNA Origami Gatekeepers for Solid-State Nanopores. Angew. Chem. Int. Ed., 51: 4864–4867. doi: 10.1002/anie.201200688

Author Information

  1. 1

    Walter Schottky Institute, Technische Universität München, Am Coulombwall 4, 85748 Garching near Munich (Germany)

  2. 2

    Center for Integrated Protein Science München & Institute for Advanced Study, Physics Department, Technische Universität München, Am Coulombwall 4a, 85748 Garching near Munich (Germany)

  1. ‡

    These authors contributed equally to this work.

*Walter Schottky Institute, Technische Universität München, Am Coulombwall 4, 85748 Garching near Munich (Germany)

  1. †

    This work was supported by the German Excellence Initiative through grants from the Nano Initiative Munich and from the Center for Integrated Protein Science Munich, by the Collaborative Research Center SFB 863 of the German Research Society (DFG), the TUM Institute for Advanced Study, and a European Research Council Starting Grant to HD. R.W. was supported by the TUM Graduate School’s Faculty Graduate Center of Physics. Discussions with Friedrich Simmel, Michael Mayer, Daniel Branton, and George Church are gratefully acknowledged.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 8 MAY 2012
  2. Article first published online: 4 APR 2012
  3. Manuscript Received: 25 JAN 2012

Funded by

  • German Research Society (DFG)

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Keywords:

  • DNA self-assembly;
  • DNA structures;
  • nanopores;
  • nanotechnology;
  • single-molecule studies
Thumbnail image of graphical abstract

DNA has it covered: DNA origami gatekeeper nanoplates convert nanopores in solid-state membranes into versatile devices for label-free macromolecular sensing applications. The custom apertures in the nanoplates can be chemically addressed for sequence-specific detection of DNA.

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