Room-Temperature Copper-Catalyzed Oxidation of Electron-Deficient Arenes and Heteroarenes Using Air

Authors

  • Qiang Liu,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
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    • These authors contributed equally to this work.

  • Pan Wu,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
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    • These authors contributed equally to this work.

  • Yuhong Yang,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
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  • Ziqi Zeng,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
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  • Jie Liu,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
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  • Hong Yi,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
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  • Prof. Aiwen Lei

    Corresponding author
    1. The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
    2. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000, Lanzhou (P.R. China)
    • The College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei (P.R. China)
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  • This work was supported by the Program for Changjiang Scholars and Innovative Research Team in University (IRT1030) and National Natural Science Foundation of China (20972118 and 20832003). We also thank Dr. Andrew Crawford for his help in revising this manuscript.

Abstract

original image

No pressure: The oxidation of aromatic C[BOND]H bonds at room temperature was realized through a copper-catalyzed “oxygenase-type” oxidation of arenes and heteroarenes in the presence of air (see scheme). The reaction involves an oxygen-atom transfer from O2 in the air onto the substrates.

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