Diastereoselective Synthesis of C3-Quaternary Indolenines Using α,β-Unsaturated N-Aryl Ketonitrones and Activated Alkynes

Authors

Errata

This article is corrected by:

  1. Errata: Corrigendum: Diastereoselective Synthesis of C3-Quaternary Indolenines Using α,β-Unsaturated N-Aryl Ketonitrones and Activated Alkynes Volume 52, Issue 49, 12770, Article first published online: 27 November 2013

  • We thank Dr. Joseph H. Reibenspies of the X-ray Diffraction Laboratory in the Department of Chemistry at Texas A&M University for X-ray crystallography analysis, Dr. Peddabuddi Gopal of the same department for some preliminary studies, and Professors Kevin Burgess and Daniel Singleton of the same department for helpful discussions. Financial support was provided by Texas A&M University and the Welch Foundation (A-1700).

Abstract

original image

New trick for an old dog: C3-Quaternary indolenines were synthesized by combining readily available α,β-unsaturated N-aryl ketonitrones and activated alkynes. This remarkably simple and atom-economical transformation does not require transition-metal catalysis and involves the formation of the heterocycles with concomitant generation of two contiguous quaternary and tertiary chiral centers.

Ancillary