This work was supported by the National Health and Medical Research Council, Australia, and the Cancer Institute New South Wales, Australia. We thank Dr. Ann Kwan for expert maintenance of the NMR spectrometers in the School of Molecular Bioscience.
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Communication
Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA†
Article first published online: 19 APR 2012
DOI: 10.1002/anie.201200866
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
O'Connell, M. R., Vandevenne, M., Nguyen, C. D., Matthews, J. M., Gamsjaeger, R., Segal, D. J. and Mackay, J. P. (2012), Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA . Angew. Chem. Int. Ed., 51: 5371–5375. doi: 10.1002/anie.201200866
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Publication History
- Issue published online: 23 MAY 2012
- Article first published online: 19 APR 2012
- Manuscript Revised: 5 MAR 2012
- Manuscript Received: 1 FEB 2012
Funded by
- National Health and Medical Research Council, Australia
- Cancer Institute New South Wales, Australia
Keywords:
- protein design;
- RNA;
- zinc-fingers
Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.