This work was supported by the National Health and Medical Research Council, Australia, and the Cancer Institute New South Wales, Australia. We thank Dr. Ann Kwan for expert maintenance of the NMR spectrometers in the School of Molecular Bioscience.
Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA†
Article first published online: 19 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 22, pages 5371–5375, May 29, 2012
How to Cite
O'Connell, M. R., Vandevenne, M., Nguyen, C. D., Matthews, J. M., Gamsjaeger, R., Segal, D. J. and Mackay, J. P. (2012), Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA . Angew. Chem. Int. Ed., 51: 5371–5375. doi: 10.1002/anie.201200866
- Issue published online: 23 MAY 2012
- Article first published online: 19 APR 2012
- Manuscript Revised: 5 MAR 2012
- Manuscript Received: 1 FEB 2012
- National Health and Medical Research Council, Australia
- Cancer Institute New South Wales, Australia
- protein design;
Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.