Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA


  • This work was supported by the National Health and Medical Research Council, Australia, and the Cancer Institute New South Wales, Australia. We thank Dr. Ann Kwan for expert maintenance of the NMR spectrometers in the School of Molecular Bioscience.


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Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.