The Reaction of a High-Valent Nonheme Oxoiron(IV) Intermediate with Hydrogen Peroxide


  • This work was supported by start-up funding from the University of Michigan (M.H.L.). J.-U.R. acknowledges support from the University of Iowa. K.P.O. is grateful for a Margaret and Herman Sokol Endowment Research Fellowship from the Department of Chemistry, University of Michigan, for the summer of 2011. We thank Chun Chow for experimental assistance.


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An FeIV[DOUBLE BOND]O group meets with H2O2! Reaction of high-valent iron with the reactive oxygen species (ROS) hydrogen peroxide (H2O2) is in general reserved for heme centers. Employing a biomimetic metal complex, the direct reaction of a mononuclear nonheme oxoiron(IV) species with H2O2 was observed and studied mechanistically, offering a new perspective for the chemistry between ROS and high-valent oxometal complexes.