Communication

A Mild Benzannulation through Directed Cycloaddition Reactions†

  1. James D. Kirkham1,
  2. Dr. Roger J. Butlin2,
  3. Prof. Joseph P. A. Harrity1,*

Article first published online: 16 MAY 2012

DOI: 10.1002/anie.201200917

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 26, pages 6402–6405, June 25, 2012

Additional Information

How to Cite

Kirkham, J. D., Butlin, R. J. and Harrity, J. P. A. (2012), A Mild Benzannulation through Directed Cycloaddition Reactions . Angew. Chem. Int. Ed., 51: 6402–6405. doi: 10.1002/anie.201200917

Author Information

  1. 1

    Department of Chemistry, University of Sheffield, Sheffield, S3 7HF (UK)

  2. 2

    Research and Development, AstraZeneca, Alderley Park, Macclesfield, SK10 4TG (UK)

*Department of Chemistry, University of Sheffield, Sheffield, S3 7HF (UK)

  1. †

    The authors are grateful to the EPSRC and AstraZeneca for financial support.

Publication History

  1. Issue published online: 21 JUN 2012
  2. Article first published online: 16 MAY 2012
  3. Manuscript Received: 2 FEB 2012

Funded by

  • EPSRC
  • AstraZeneca

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Keywords:

  • boron;
  • cross-coupling;
  • cycloaddition;
  • heterocycles;
  • synthetic methods
Thumbnail image of graphical abstract

Simple as ABC: Alkynyl borane cycloadditions can be substrate-directed to assemble aromatic difluoroboranes within an extremely mild and efficient reaction manifold compared to that of traditional methods (see scheme). The aromatic boranes are readily transformed into a range of useful products.

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