MAD as an additive: The [Ni(cod)2], (2,6-tBu2-4-MeC6H2O)2AlMe (MAD), and N-heterocyclic carbene (NHC) catalytic system effected a highly regioselective alkylation of pyridone derivatives (see scheme). Substituted pyridones and related heterocycles react with both terminal and internal alkenes to selectively give a range of nitrogen-containing heterocycles with linear alkyl substituents.
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