SEARCH

SEARCH BY CITATION

Keywords:

  • amides;
  • asymmetric synthesis;
  • cinchona alkaloids;
  • Michael addition;
  • organocatalysis
Thumbnail image of graphical abstract

Amide nucleophiles on demand: Rationally designed pyrazoleamides function as Michael donors in urea-catalyzed asymmetric Michael reactions with excellent chemical and optical yields (see scheme). The pyrazoleamide group performs as an ester equivalent, a directing group, an activating group, and functions as a good leaving group in further transformations of the product.