The authors acknowledge the NIH-NIGMS (GM 098314) and the University of Michigan Associate Professor Support Fund for financial support of this work. Additional funding was provided by GlaxoSmithKline and Amgen.
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Communication
Asymmetric Total Synthesis of (+)-Merobatzelladine B†
Article first published online: 16 MAR 2012
DOI: 10.1002/anie.201201001
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Babij, N. R. and Wolfe, J. P. (2012), Asymmetric Total Synthesis of (+)-Merobatzelladine B . Angew. Chem. Int. Ed., 51: 4128–4130. doi: 10.1002/anie.201201001
- †
Publication History
- Issue published online: 19 APR 2012
- Article first published online: 16 MAR 2012
- Manuscript Received: 7 FEB 2012
Funded by
- NIH-NIGMS. Grant Number: GM 098314
- University of Michigan Associate Professor Support Fund
- GlaxoSmithKline
- Amgen
Keywords:
- alkaloids;
- asymmetric synthesis;
- natural products;
- palladium;
- total synthesis
Putting the syn in synthesis: The first total synthesis of (+)-merobatzelladine B was accomplished using an iterative sequence of stereoselective palladium-catalyzed alkene carboamination reactions for formation of two of the three rings. This represents a new strategy for the generation of polycyclic guanidine natural products, and provides access to compounds with a syn relationship between the C6 hydrogen atom and the C8 alkyl group.