This work was supported by the National Natural Science Foundation of China (21025206, 20832003, and 20972118) and the 973 Program (2012CB725302).
Palladium-Catalyzed Oxidative Double CH Functionalization/Carbonylation for the Synthesis of Xanthones†
Article first published online: 4 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 21, pages 5204–5207, May 21, 2012
How to Cite
Zhang, H., Shi, R., Gan, P., Liu, C., Ding, A., Wang, Q. and Lei, A. (2012), Palladium-Catalyzed Oxidative Double CH Functionalization/Carbonylation for the Synthesis of Xanthones . Angew. Chem. Int. Ed., 51: 5204–5207. doi: 10.1002/anie.201201050
- Issue published online: 15 MAY 2012
- Article first published online: 4 APR 2012
- Manuscript Received: 8 FEB 2012
- National Natural Science Foundation of China. Grant Numbers: 21025206, 20832003, 20972118, 2012CB725302
- CH activation;
- oxidative carbonylation;
- synthetic methods;
Two at once: Xanthones with different functional groups were obtained with CO (balloon) in the presence of a simple catalytic system that consists of Pd(OAc)2, K2S2O8, and trifluoroacetic acid (see scheme). Preliminary mechanism studies reveal that the second CH functionalization might be the rate-determining step.