Palladium-Catalyzed Oxidative Double C[BOND]H Functionalization/Carbonylation for the Synthesis of Xanthones


  • This work was supported by the National Natural Science Foundation of China (21025206, 20832003, and 20972118) and the 973 Program (2012CB725302).


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Two at once: Xanthones with different functional groups were obtained with CO (balloon) in the presence of a simple catalytic system that consists of Pd(OAc)2, K2S2O8, and trifluoroacetic acid (see scheme). Preliminary mechanism studies reveal that the second C[BOND]H functionalization might be the rate-determining step.