This work was supported by ETH Research Grant ETH-12 11-1 and the ETH-Zürich. We are grateful to Noel Ellis (Univ. Penn.) for a gift of 1 a and to David Furrer, Lei Ju, and Shouyun Yu for preliminary experiments.
Amide-Forming Ligation of Acyltrifluoroborates and Hydroxylamines in Water†
Article first published online: 26 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 23, pages 5683–5686, June 4, 2012
How to Cite
Dumas, A. M., Molander, G. A. and Bode, J. W. (2012), Amide-Forming Ligation of Acyltrifluoroborates and Hydroxylamines in Water. Angew. Chem. Int. Ed., 51: 5683–5686. doi: 10.1002/anie.201201077
- Issue published online: 30 MAY 2012
- Article first published online: 26 APR 2012
- Manuscript Received: 8 FEB 2012
- ETH Research Grant. Grant Number: ETH-12 11-1
Come together, right now: Acyltrifluoroborates and O-benzoyl hydroxylamines come together to form amides in water (see scheme). The ligations are complete within minutes at room temperature and do not require any reagents or catalysts. The reaction has a broad substrate scope and tolerates unprotected functional groups.