Human α2-Macroglobulin—Another Variation on the Venus Flytrap

Authors


Abstract

original image

Trapping proteinases: The mechanism of the nonspecific human proteinase inhibitor α2-macroglobulin (α2M, about 6000 amino acid residues) is reminiscent of a Venus flytrap (see scheme). The structure of α2M was solved recently with a resolution of 4.3 Å even though only one single crystal was available.

Ancillary