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Keywords:

  • cyclization;
  • diversity-oriented synthesis;
  • metathesis;
  • natural products;
  • transition metals
Thumbnail image of graphical abstract

Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products.