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Keywords:

  • cyclizations;
  • heterocycles;
  • natural products;
  • silanes;
  • synthetic methods
Thumbnail image of graphical abstract

Prins Charming: Prins cyclization of a bis(silyl) homoallylic alcohol with an aldehyde shows excellent cis and Z selectivity to form tetrahydropyrans containing a geometrically defined exocyclic vinylsilane. This reaction was used as the key step in the synthesis of ring B of the bryostatins.