These authors contributed equally to this work.
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation†
Article first published online: 8 MAY 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 25, pages 6140–6143, June 18, 2012
How to Cite
Sun, Q., Burke, J. P., Phan, J., Burns, M. C., Olejniczak, E. T., Waterson, A. G., Lee, T., Rossanese, O. W. and Fesik, S. W. (2012), Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation . Angew. Chem. Int. Ed., 51: 6140–6143. doi: 10.1002/anie.201201358
This work was supported by the US National Institutes of Health: 5DP1OD006933 (NIH Director’s Pioneer Award) to S.W.F., an ARRA stimulus grant (5RC2A148375) to L. J. Marnett, and a NCI SPORE grant in GI cancer (5P50A095103-09) to R.J. Coffey. This work was also funded by the Lustgarten Foundation grant awarded to S.W.F. and the American Cancer Society (Postdoctoral Fellowship, PF1110501CDD) to J.P.B. We thank Matt Mulder (Craig Lindsley lab, Vanderbilt University) for providing HRMS data.
- Issue published online: 13 JUN 2012
- Article first published online: 8 MAY 2012
- Manuscript Received: 17 FEB 2012
- US National Institutes of Health. Grant Number: 5DP1OD006933
- ARRA. Grant Number: 5RC2A148375
- NCI SPORE. Grant Number: 5P50A095103-09
- Lustgarten Foundation
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