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Knölker’s Iron Complex: An Efficient In Situ Generated Catalyst for Reductive Amination of Alkyl Aldehydes and Amines

Authors

  • Anastassiya Pagnoux-Ozherelyeva,

    1. Laboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, INC3M, FR 3038, ENSICAEN-University of Caen, 14050 Caen (France)
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  • Dr. Nicolas Pannetier,

    1. Laboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, INC3M, FR 3038, ENSICAEN-University of Caen, 14050 Caen (France)
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  • Dr. Mbaye Diagne Mbaye,

    1. Laboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, INC3M, FR 3038, ENSICAEN-University of Caen, 14050 Caen (France)
    2. University of Ziguinchor, BP 523 Ziguinchor (Senegal)
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  • Dr. Sylvain Gaillard,

    1. Laboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, INC3M, FR 3038, ENSICAEN-University of Caen, 14050 Caen (France)
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  • Prof. Jean-Luc Renaud

    Corresponding author
    1. Laboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, INC3M, FR 3038, ENSICAEN-University of Caen, 14050 Caen (France)
    • Laboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, INC3M, FR 3038, ENSICAEN-University of Caen, 14050 Caen (France)
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  • The “Ministère de la Recherche et des Nouvelles Technologies” is gratefully acknowledged for a PhD grant (A.P.-O.). The CNRS (Centre National de la Recherche Scientifique) and “Région Basse-Normandie” are acknowledged for financial support. We thank Oril Industries for a Post-Doc. fellowship (N.P.) and the University of Ziguinchor for a fellowship to M.D.M. Rhodia is acknowledged for the generous gift of bistriflimide.

Abstract

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An aminated series: A well-defined iron-catalyzed reductive amination reaction of aldehydes and ketones with aliphatic amines using molecular hydrogen is presented. Under mild conditions, good yields for a broad range of alkyl ketones as well as aldehydes were achieved.

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