Turning “On” and “Off” a Pyridoxal 5′-Phosphate Mimic Using Light

Authors

  • Danielle Wilson,

    1. Department of Chemistry and 4D LABS, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A1S6 (Canada)
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  • Prof. Neil R. Branda

    Corresponding author
    1. Department of Chemistry and 4D LABS, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A1S6 (Canada)
    • Department of Chemistry and 4D LABS, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A1S6 (Canada)
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  • This research was supported by the Natural Sciences and Engineering Research Council (NSERC) of Canada, the Canada Research Chairs Program, and Simon Fraser University.

Abstract

original image

Light is used to toggle a photoresponsive mimic of the cofactor pyridoxal phosphate between two isomers, where only one of them can catalyze the racemization of an amino acid. The system is based on creating and breaking electronic communication between the two catalyst components, i.e., an aldehyde and a pyridinium cation.

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