SEARCH

SEARCH BY CITATION

Keywords:

  • copper;
  • high-throughput screening;
  • immunoassays;
  • reaction discovery
Thumbnail image of graphical abstract

Mmm, a reaction sandwich… Using an immunoassay-based technique able to monitor any kind of cross-coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper-promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N-hydroxy thioureas.