Communication

Reaction Discovery by Using a Sandwich Immunoassay†

  1. Dr. Julia Quinton1,
  2. Sergii Kolodych1,
  3. Dr. Manon Chaumonet1,
  4. Valentina Bevilacqua1,
  5. Marie-Claire Nevers2,
  6. Dr. Hervé Volland2,
  7. Sandra Gabillet1,
  8. Dr. Pierre Thuéry3,
  9. Dr. Christophe Créminon2,
  10. Dr. Frédéric Taran1,*

Article first published online: 4 MAY 2012

DOI: 10.1002/anie.201201451

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 25, pages 6144–6148, June 18, 2012

Additional Information

How to Cite

Quinton, J., Kolodych, S., Chaumonet, M., Bevilacqua, V., Nevers, M.-C., Volland, H., Gabillet, S., Thuéry, P., Créminon, C. and Taran, F. (2012), Reaction Discovery by Using a Sandwich Immunoassay . Angew. Chem. Int. Ed., 51: 6144–6148. doi: 10.1002/anie.201201451

Author Information

  1. 1

    CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif sur Yvette (France)

  2. 2

    CEA, iBiTecS, Service de Pharmacologie et d'Immunoanalyse, 91191 Gif sur Yvette (France)

  3. 3

    CEA, IRAMIS, Service Interdisciplinaire sur les Systèmes, Moléculaires et les Matériaux, 91191 Gif sur Yvette (France)

*CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif sur Yvette (France)

  1. †

    This work was supported by the European Union, BioChemLig project and by ANR, ClickScreen project.

Publication History

  1. Issue published online: 13 JUN 2012
  2. Article first published online: 4 MAY 2012
  3. Manuscript Revised: 10 APR 2012
  4. Manuscript Received: 21 FEB 2012

Funded by

  • European Union
  • BioChemLig
  • ANR

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Keywords:

  • copper;
  • high-throughput screening;
  • immunoassays;
  • reaction discovery
Thumbnail image of graphical abstract

Mmm, a reaction sandwich… Using an immunoassay-based technique able to monitor any kind of cross-coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper-promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N-hydroxy thioureas.

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