This work was supported by the European Union, BioChemLig project and by ANR, ClickScreen project.
Reaction Discovery by Using a Sandwich Immunoassay†
Article first published online: 4 MAY 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 25, pages 6144–6148, June 18, 2012
How to Cite
Quinton, J., Kolodych, S., Chaumonet, M., Bevilacqua, V., Nevers, M.-C., Volland, H., Gabillet, S., Thuéry, P., Créminon, C. and Taran, F. (2012), Reaction Discovery by Using a Sandwich Immunoassay . Angew. Chem. Int. Ed., 51: 6144–6148. doi: 10.1002/anie.201201451
- Issue published online: 13 JUN 2012
- Article first published online: 4 MAY 2012
- Manuscript Revised: 10 APR 2012
- Manuscript Received: 21 FEB 2012
- European Union
- high-throughput screening;
- reaction discovery
Mmm, a reaction sandwich… Using an immunoassay-based technique able to monitor any kind of cross-coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper-promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N-hydroxy thioureas.