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Reaction Discovery by Using a Sandwich Immunoassay


  • This work was supported by the European Union, BioChemLig project and by ANR, ClickScreen project.


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Mmm, a reaction sandwich… Using an immunoassay-based technique able to monitor any kind of cross-coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper-promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N-hydroxy thioureas.