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Keywords:

  • adeno-associated virus;
  • catechol;
  • gene expression;
  • spatially patterned gene delivery;
  • viruses
Thumbnail image of graphical abstract

Sticky stuff: A versatile strategy to spatially control gene expressions of mammalian cells is developed. A catecholamine polymer (PEI-C) is used to functionalize surfaces of adeno-associated viruses (AAV). Because of the underwater adhesive property of catechol, AAV/PEI-C hybrid vectors become highly “sticky”, resulting in spatially patterned viral attachment onto substrates by the simple “gene-vector drawing” technique (see picture).