Synthesis of Fluorene Derivatives through Rhodium-Catalyzed Dehydrogenative Cyclization


  • This work was partly supported by Grants-in-Aid from the MEXT and JSPS (Japan).


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Doubling up: Two C[BOND]H bond activations took place efficiently upon treatment of 1 with a rhodium catalyst to form dehydrogenative cyclization products 2. Furthermore, 3 undergoes similar cyclization and subsequent decarboxylation through the cleavage of two C[BOND]H bonds and one C[BOND]C bond. Both reactions provide straightforward routes to the fluorene framework.