This work was partly supported by Grants-in-Aid from the MEXT and JSPS (Japan).
Synthesis of Fluorene Derivatives through Rhodium-Catalyzed Dehydrogenative Cyclization†
Article first published online: 19 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 22, pages 5359–5362, May 29, 2012
How to Cite
Morimoto, K., Itoh, M., Hirano, K., Satoh, T., Shibata, Y., Tanaka, K. and Miura, M. (2012), Synthesis of Fluorene Derivatives through Rhodium-Catalyzed Dehydrogenative Cyclization . Angew. Chem. Int. Ed., 51: 5359–5362. doi: 10.1002/anie.201201526
- Issue published online: 23 MAY 2012
- Article first published online: 19 APR 2012
- Manuscript Revised: 23 MAR 2012
- Manuscript Received: 24 FEB 2012
- CC coupling;
- CH activation;
- homogeneous catalysis;
Doubling up: Two CH bond activations took place efficiently upon treatment of 1 with a rhodium catalyst to form dehydrogenative cyclization products 2. Furthermore, 3 undergoes similar cyclization and subsequent decarboxylation through the cleavage of two CH bonds and one CC bond. Both reactions provide straightforward routes to the fluorene framework.