Copper-Catalyzed Tandem C[BOND]N Bond Formation: An Efficient Annulative Synthesis of Functionalized Cinnolines


  • This work was supported by the EPSRC and Eli Lilly.


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Cinn-tillating synthesis: The combination of a readily available copper catalyst, a simple hydrazide nucleophile, and established difunctionalized building blocks provides a new, flexible route to an under-developed class of aromatic heterocycles, cinnolines (see scheme).