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Keywords:

  • electrophilic addition;
  • hypervalent compounds;
  • nitrogen heterocycles;
  • synthetic methods;
  • trifluoromethylation
Thumbnail image of graphical abstract

Effective CF3 transfer: Various electron-rich nitrogen heterocycles (pyrazoles, triazoles, and tetrazoles) can be directly N-trifluoromethylated by a hypervalent iodine reagent in an efficient manner. The optimized procedure, which includes an in situ silylation of the substrate followed by an acid-catalyzed CF3 transfer, provides ready access to a series of new and previously challenging or inaccessible NCF3 compounds.