We thank the EPFL (Switzerland), the Swiss National Science Foundation (SNF), and the Swiss National Centres of Competence in Research (NCCR) for financial support.
Palladium(II)-Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion†
Article first published online: 12 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 21, pages 5170–5174, May 21, 2012
How to Cite
Yao, B., Wang, Q. and Zhu, J. (2012), Palladium(II)-Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion . Angew. Chem. Int. Ed., 51: 5170–5174. doi: 10.1002/anie.201201640
- Issue published online: 15 MAY 2012
- Article first published online: 12 APR 2012
- Manuscript Received: 29 FEB 2012
- EPFL (Switzerland)
- Swiss National Science Foundation (SNF)
- Swiss National Centres of Competence in Research (NCCR)
- domino reactions;
“I” did it: A sequential intramolecular amination/N-demethylation/amidation of internal acetylenes in the presence of a catalytic amount of Pd(OAc)2 and nBu4NI afforded indolo[3,2-c]isoquinolinones under mild aerobic conditions (see scheme, DMSO=dimethyl sulfoxide). The iodide ion was regenerated by reaction of in situ generated MeI with HOAc present in the reaction mixture.