Neutral Nazarov-Type Cyclization Catalyzed by Palladium(0)


  • We thank the NIH-NIGMS (R01 GM57873) for generous support.


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Joining the circle: The first Pd0 catalyzed Nazarov-type cyclization of diketoesters (see scheme) proceeds in 70 % to 95 % yield under strictly neutral pH conditions. Aryl substitution of the diketoesters is not required, so the reaction shows great versatility and can also proceed with aliphatic substrates.