We thank Singapore National Research Foundation (NRF-RF2008-10) and Nanyang Technological University for financial support and Johnson-Matthey for a gift of palladium.
Intermolecular Mizoroki–Heck Reaction of Aliphatic Olefins with High Selectivity for Substitution at the Internal Position†
Article first published online: 3 MAY 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 24, pages 5915–5919, June 11, 2012
How to Cite
Qin, L., Ren, X., Lu, Y., Li, Y. and Zhou, J. (2012), Intermolecular Mizoroki–Heck Reaction of Aliphatic Olefins with High Selectivity for Substitution at the Internal Position. Angew. Chem. Int. Ed., 51: 5915–5919. doi: 10.1002/anie.201201806
- Issue published online: 5 JUN 2012
- Article first published online: 3 MAY 2012
- Manuscript Received: 6 MAR 2012
- National Research Foundation. Grant Number: NRF-RF2008-10
- Nanyang Technological University
- Heck reaction;
- palladium catalysis;
New ligand for old reaction: The title reaction of aryltriflates with aliphatic olefins leads to substitution at the internal position with high selectivity. The ratio of the desired isomer (shown in the scheme) to the sum of all other isomers is generally above 10:1. The key to success is the use of a ferrocene bisphosphine ligand (R= 1-naphthyl). The reaction can be easily scaled up, and minor isomers can be separated by chromatography.