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Keywords:

  • actin;
  • macrolides;
  • natural products;
  • polyketides;
  • total synthesis
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Symmetry helps: The total synthesis of the potent actin-targeting C2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains.