This work was supported by the National Natural Science Foundation of China (21025206, 20832003, and 20972118) and the 973 Program (2012CB725302).
Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols†
Article first published online: 26 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 23, pages 5662–5666, June 4, 2012
How to Cite
Liu, C., Tang, S., Zheng, L., Liu, D., Zhang, H. and Lei, A. (2012), Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols. Angew. Chem. Int. Ed., 51: 5662–5666. doi: 10.1002/anie.201201960
- Issue published online: 30 MAY 2012
- Article first published online: 26 APR 2012
- Manuscript Received: 12 MAR 2012
- National Natural Science Foundation of China. Grant Numbers: 21025206, 20832003, 20972118
- 973 Program. Grant Number: 2012CB725302
- ligand design;
It's a benzyl kind of magic: In the title reaction proceeding with benzyl chloride as the oxidant, the benzyl group serves as a carbon ligand, thus having an η3-coordination effect on palladium (see scheme). A variety of aldehydes and alcohols were selectively converted into the corresponding esters in good to excellent yields.