Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols


  • This work was supported by the National Natural Science Foundation of China (21025206, 20832003, and 20972118) and the 973 Program (2012CB725302).


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It's a benzyl kind of magic: In the title reaction proceeding with benzyl chloride as the oxidant, the benzyl group serves as a carbon ligand, thus having an η3-coordination effect on palladium (see scheme). A variety of aldehydes and alcohols were selectively converted into the corresponding esters in good to excellent yields.