These authors contributed equally to this work.
Peptide-Mediated Blood–Brain Barrier Transport of Polymersomes†
Article first published online: 11 JUL 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 33, pages 8339–8342, August 13, 2012
How to Cite
Georgieva, J. V., Brinkhuis, R. P., Stojanov, K., Weijers, C. A. G. M., Zuilhof, H., Rutjes, F. P. J. T., Hoekstra, D., van Hest, J. C. M. and Zuhorn, I. S. (2012), Peptide-Mediated Blood–Brain Barrier Transport of Polymersomes . Angew. Chem. Int. Ed., 51: 8339–8342. doi: 10.1002/anie.201202001
This work was performed within the framework of the Dutch Top Institute Pharma project number T5-105. Hans Adams is acknowledged for his help with peptide synthesis. Microscopy imaging was performed at the UMCG Imaging Center (UMIC), supported by the Netherlands Organisation for Health Research and Development (ZonMW grant 40-00506-98-9021).
- Issue published online: 7 AUG 2012
- Article first published online: 11 JUL 2012
- Manuscript Revised: 20 JUN 2012
- Manuscript Received: 13 MAR 2012
- bioorganic chemistry;
- blood–brain barrier;
- drug delivery;
A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.