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Peptide-Mediated Blood–Brain Barrier Transport of Polymersomes

Authors

  • Julia V. Georgieva,

    1. Department of Cell Biology, Section Membrane Biology, University Medical Center Groningen, Groningen University, A. Deusinglaan 1, 9713AV Groningen (The Netherlands)
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    • These authors contributed equally to this work.

  • René P. Brinkhuis,

    1. Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525AJ Nijmegen (The Netherlands)
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    • These authors contributed equally to this work.

  • Katica Stojanov,

    1. Department of Cell Biology, Section Membrane Biology, University Medical Center Groningen, Groningen University, A. Deusinglaan 1, 9713AV Groningen (The Netherlands)
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  • Dr. Carel A. G. M. Weijers,

    1. Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen (The Netherlands)
    2. Department of Chemical and Materials Enginering, King Abdulaziz University, Jeddah (Saudi Arabia)
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  • Prof. Dr. Han Zuilhof,

    1. Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen (The Netherlands)
    2. Department of Chemical and Materials Enginering, King Abdulaziz University, Jeddah (Saudi Arabia)
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  • Prof. Dr. Floris P. J. T. Rutjes,

    1. Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525AJ Nijmegen (The Netherlands)
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  • Prof. Dr. Dick Hoekstra,

    1. Department of Cell Biology, Section Membrane Biology, University Medical Center Groningen, Groningen University, A. Deusinglaan 1, 9713AV Groningen (The Netherlands)
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  • Prof. Dr. Jan C. M. van Hest,

    Corresponding author
    1. Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525AJ Nijmegen (The Netherlands)
    • Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525AJ Nijmegen (The Netherlands)
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  • Dr. Inge S. Zuhorn

    Corresponding author
    1. Department of Cell Biology, Section Membrane Biology, University Medical Center Groningen, Groningen University, A. Deusinglaan 1, 9713AV Groningen (The Netherlands)
    • Department of Cell Biology, Section Membrane Biology, University Medical Center Groningen, Groningen University, A. Deusinglaan 1, 9713AV Groningen (The Netherlands)
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  • This work was performed within the framework of the Dutch Top Institute Pharma project number T5-105. Hans Adams is acknowledged for his help with peptide synthesis. Microscopy imaging was performed at the UMCG Imaging Center (UMIC), supported by the Netherlands Organisation for Health Research and Development (ZonMW grant 40-00506-98-9021).

Abstract

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A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.

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