Cover Picture: Chemical Protein Synthesis by Chemoselective α-Ketoacid–Hydroxylamine (KAHA) Ligations with 5-Oxaproline (Angew. Chem. Int. Ed. 21/2012)



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Chemoselective ligations of two unprotected protein segments that give a native amide bond are valued reactions for the synthesis of proteins. In their Communication on page 5114 ff., J. W. Bode et al. show that the α-ketoacid—hydroxylamine (KAHA) ligation with 5-oxaproline is an efficient reaction for the synthesis of proteins with unprotected protein segments in aqueous buffers. Prokaryotic ubiquitin-like protein and probable cold shock protein A have been synthesized.