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Keywords:

  • amides;
  • ligation reactions;
  • peptides;
  • protein synthesis;
  • proteins
Thumbnail image of graphical abstract

Chemoselective ligations of two unprotected protein segments that give a native amide bond are valued reactions for the synthesis of proteins. In their Communication on page 5114 ff., J. W. Bode et al. show that the α-ketoacid—hydroxylamine (KAHA) ligation with 5-oxaproline is an efficient reaction for the synthesis of proteins with unprotected protein segments in aqueous buffers. Prokaryotic ubiquitin-like protein and probable cold shock protein A have been synthesized.