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Communication

A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity†

  1. Dr. Oliver Demmer1,2,
  2. Dr. Andreas O. Frank1,2,
  3. Dr. Franz Hagn1,2,
  4. Dr. Margret Schottelius3,
  5. Prof. Dr. Luciana Marinelli4,
  6. Dr. Sandro Cosconati5,
  7. Prof. Dr. Ruth Brack-Werner6,
  8. Dr. Stephan Kremb6,
  9. Prof. Dr. Hans-Jürgen Wester3,
  10. Prof. Dr. Horst Kessler1,2,*

Article first published online: 3 JUL 2012

DOI: 10.1002/anie.201202090

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 32, pages 8110–8113, August 6, 2012

Additional Information

How to Cite

Demmer, O., Frank, A. O., Hagn, F., Schottelius, M., Marinelli, L., Cosconati, S., Brack-Werner, R., Kremb, S., Wester, H.-J. and Kessler, H. (2012), A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity. Angew. Chem. Int. Ed., 51: 8110–8113. doi: 10.1002/anie.201202090

Author Information

  1. 1

    Institute for Advanced Study at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching (Germany) http://www.org.chemie.tu-muenchen.de

  2. 2

    Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia)

  3. 3

    Lehrstuhl für Pharmazeutische Radiochemie, Garching (Germany)

  4. 4

    Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli “Federico II”, Napoli (Italy)

  5. 5

    Dipartimento di Scienze Ambientali, Seconda Università di Napoli, Caserta (Italy)

  6. 6

    Helmholtz Zentrum München, Institute of Virology Neuherberg/München (Germany)

*Institute for Advanced Study at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching (Germany) http://www.org.chemie.tu-muenchen.de

  1. †

    We thank M. Wolff and B. Cordes for technical assistance and E. Gourni for the help in the cell binding assay. This work was supported by the Center of Integrated Protein Science Munich (CIPS). Financial support by the DFG (SFB824, Subproject B5) is acknowledged. The representation of the HI virus in the Table of Contents graphic was originally created by the US National Institute of Health (Permission: PD-USGov-HHS-NIH)

Publication History

  1. Issue published online: 1 AUG 2012
  2. Article first published online: 3 JUL 2012
  3. Manuscript Revised: 2 MAY 2012
  4. Manuscript Received: 16 MAR 2012

Funded by

  • DFG

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