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Keywords:

  • NMR spectroscopy;
  • prions;
  • protein structures;
  • solid-state NMR spectroscopy;
  • Ure2p
Thumbnail image of graphical abstract

Taking a definite stance: Protein fibrils are often associated with disorder and polymorphism, but the prion fibrils of Ure2p are shown (through solid-state NMR spectroscopy) to be highly ordered, and the conformations of the globular domain to be more restricted within the fibrils (black; see scheme) than in Ure2p single crystals (red). This finding implies that steric impairment is at the origin of the [URE3] phenotype in yeast.