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Keywords:

  • aromatic substitution;
  • cross-coupling;
  • heterocycles;
  • microwave chemistry;
  • nucleophilic substitution
Thumbnail image of graphical abstract

Caught in a ‘SNAr'e: A one-step, high-yielding, catalyst-free method is described for N-arylation of azoles and indoles from unactivated monofluorobenzenes. This SNAr reaction tolerates a wide range of substituents and can also generate halogenated N-aryl products. The reaction can also be performed simultaneously with or subsequent to a copper- or palladium-catalyzed cross-coupling reaction in the same pot.