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Cover Picture
Cover Picture: Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis (Angew. Chem. Int. Ed. 22/2012)
Article first published online: 5 APR 2012
DOI: 10.1002/anie.201202174
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Park, J., Oh, S. and Park, S. B. (2012), Cover Picture: Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis (Angew. Chem. Int. Ed. 22/2012). Angew. Chem. Int. Ed., 51: 5259. doi: 10.1002/anie.201202174
Publication History
- Issue published online: 23 MAY 2012
- Article first published online: 5 APR 2012
Keywords:
- antiproliferative agents;
- click reaction;
- drug discovery;
- photoaffinity labeling;
- target identification
Target identification is the crown jewel of chemical biology. In their Communication on page 5447 ff., S. B. Park et al. have developed a new target identification method, fluorescence difference in two-dimensional gel electrophoresis (FITGE), to observe the interactions between proteins and small molecules in an intact cellular environment. FITGE successfully identifies protein differentiation between specific and nonspecific binding of photoaffinity probes.