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Keywords:

  • antiproliferative agents;
  • click reaction;
  • drug discovery;
  • photoaffinity labeling;
  • target identification
Thumbnail image of graphical abstract

Target identification is the crown jewel of chemical biology. In their Communication on page 5447 ff., S. B. Park et al. have developed a new target identification method, fluorescence difference in two-dimensional gel electrophoresis (FITGE), to observe the interactions between proteins and small molecules in an intact cellular environment. FITGE successfully identifies protein differentiation between specific and nonspecific binding of photoaffinity probes.