Cover Picture: Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis (Angew. Chem. Int. Ed. 22/2012)

Authors

  • Jongmin Park,

    1. Department of Chemistry, College of Natural Science, Seoul National University, Seoul 151-747 (Korea)
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  • Dr. Sangmi Oh,

    1. Department of Chemistry, College of Natural Science, Seoul National University, Seoul 151-747 (Korea)
    2. Current address: Medicinal Chemistry and Chemical Biology Group, Institut Pasteur Korea, Gyeonggi 463-400 (Korea)
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  • Prof. Seung Bum Park

    Corresponding author
    1. Department of Chemistry, College of Natural Science, Seoul National University, Seoul 151-747 (Korea)
    2. Department of Biophysics and Chemical Biology/Bio-MAX institute Seoul National University, Seoul 151-747 (Korea)
    • Department of Chemistry, College of Natural Science, Seoul National University, Seoul 151-747 (Korea)
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Abstract

original image

Target identification is the crown jewel of chemical biology. In their Communication on page 5447 ff., S. B. Park et al. have developed a new target identification method, fluorescence difference in two-dimensional gel electrophoresis (FITGE), to observe the interactions between proteins and small molecules in an intact cellular environment. FITGE successfully identifies protein differentiation between specific and nonspecific binding of photoaffinity probes.

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