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Keywords:

  • 1,4-addition;
  • β-arylation;
  • asymmetric catalysis;
  • flow chemistry;
  • multistep reactions
Thumbnail image of graphical abstract

The first multistep asymmetric catalysis in flow has been realized using a lithiation/borylation/rhodium-catalyzed 1,4-addition sequence. The three-step sequence starts from readily available and inexpensive aryl bromides, affording β-arylated ketones in good yields with high levels of enantioselectivity.