W.S. and S.L.B. thank Novartis International AG for funding. The Varian NMR instrument used was supported by the National Institutes of Health (Grant No. CHE 9808061). We thank Dr. Meredeth A. McGowan and Dr. Christine Nguyen for assistance with the preparation of this manuscript.
Enantioselective β-Arylation of Ketones Enabled by Lithiation/Borylation/1,4-Addition Sequence Under Flow Conditions†
Article first published online: 18 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 22, pages 5355–5358, May 29, 2012
How to Cite
Shu, W. and Buchwald, S. L. (2012), Enantioselective β-Arylation of Ketones Enabled by Lithiation/Borylation/1,4-Addition Sequence Under Flow Conditions . Angew. Chem. Int. Ed., 51: 5355–5358. doi: 10.1002/anie.201202221
- Issue published online: 23 MAY 2012
- Article first published online: 18 APR 2012
- Manuscript Received: 20 MAR 2012
- National Institutes of Health. Grant Number: CHE 9808061
- asymmetric catalysis;
- flow chemistry;
- multistep reactions
The first multistep asymmetric catalysis in flow has been realized using a lithiation/borylation/rhodium-catalyzed 1,4-addition sequence. The three-step sequence starts from readily available and inexpensive aryl bromides, affording β-arylated ketones in good yields with high levels of enantioselectivity.