We are grateful to Dr. Mackay B. Steffensen, Dr. Hai-Chen Wu, Dr. Dvir Rotem, and Dr. Tivadar Mach for their ideas and helpful discussions, Dr. Barbara Odell and Dr. Timothy D. W. Claridge for 15N NMR spectroscopy, Dr. Jeffrey Harmer for EPR spectroscopy, and Dr. Arnold J. Boersma and Dr. Sarah E. Rogers for reading the manuscript. This work was supported by the MRC. L.-S.C. is the recipient of a University of Oxford Croucher Scholarship (UOCS).
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Communication
S-Nitrosothiol Chemistry at the Single-Molecule Level†
Article first published online: 4 JUL 2012
DOI: 10.1002/anie.201202365
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Choi, L.-S. and Bayley, H. (2012), S-Nitrosothiol Chemistry at the Single-Molecule Level. Angew. Chem. Int. Ed., 51: 7972–7976. doi: 10.1002/anie.201202365
- †
Publication History
- Issue published online: 1 AUG 2012
- Article first published online: 4 JUL 2012
- Manuscript Revised: 8 JUN 2012
- Manuscript Received: 26 MAR 2012
Funded by
- MRC
- University of Oxford
Keywords:
- nitroxyl;
- signal transduction;
- single-molecule studies;
- S-nitrosothiol;
- sulfite
SNO patrol: S-Nitrosothiols (RSNO) are important molecules involved in cell signaling, which control physiological processes such as vasodilation and bronchodilation. By using the protein pore α-hemolysin as a nanoreactor, the biological chemistry of RSNO has been investigated at the single-molecule level (see scheme).