Cobalt-Catalyzed Direct Arylation and Benzylation by C[BOND]H/C[BOND]O Cleavage with Sulfamates, Carbamates, and Phosphates


  • Support by the DFG, the Georg-August-Universität Göttingen, and the Chinese Scholarship Council (fellowship to W.S.) is gratefully acknowledged. We thank Ayesha Babar for the synthesis of starting materials, as well as Dr. Benudhar Punji for helpful discussions and preliminary experiments with aryl chlorides.


original image

Inexpensive cobalt catalysts enable the first direct arylation and benzylation of (hetero)arenes with aryl carbamates, sulfamates, and phosphates with ample scope. The non-radical C[BOND]H/C[BOND]O arylation reaction even proved viable at ambient temperature.