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Keywords:

  • binding mode;
  • drug discovery;
  • ligand design;
  • protein structures;
  • structure–activity relationships
Thumbnail image of graphical abstract

Probing the pocket: A high-throughput fluorescence-based thermal shift (FTS) assay utilized different forms of a protein (in gray) to establish the binding mode of a ligand (see picture). The assay serves in the rapid evaluation of structure–activity binding-mode relationships for a series of ligands of Plk1, an important target of anticancer therapy.