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Keywords:

  • aldol reaction;
  • cyclization;
  • heterocycles;
  • synthetic methods;
  • titanium
Thumbnail image of graphical abstract

High octane: A novel and practical syntheses of 8-oxabicyclo[3.2.1]octanes using a cationic cascade cyclization reaction has been developed (see scheme; TIPS=triisopropylsilyl). The diastereomer of the cyclization product isolated depends upon whether the acetal or aldehyde substrate is used.