Communication

Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography†

  1. Dr. Alexander G. O'Brien1,
  2. Zoltán Horváth3,
  3. Dr. François Lévesque1,
  4. Dr. Ju Weon Lee3,
  5. Prof. Dr. Andreas Seidel-Morgenstern3,
  6. Prof. Dr. Peter H. Seeberger1,2,*

Article first published online: 6 JUN 2012

DOI: 10.1002/anie.201202795

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 28, pages 7028–7030, July 9, 2012

Additional Information

How to Cite

O'Brien, A. G., Horváth, Z., Lévesque, F., Lee, J. W., Seidel-Morgenstern, A. and Seeberger, P. H. (2012), Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography . Angew. Chem. Int. Ed., 51: 7028–7030. doi: 10.1002/anie.201202795

Author Information

  1. 1

    Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

  2. 2

    Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany) http://www.mpikg.mpg.de

  3. 3

    Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg (Germany)

*Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

  1. †

    We thank the Max-Planck Society and AstraZeneca UK for generous financial support. F.L. is the recipient of a postdoctoral fellowship from Fonds québécois de la recherche sur la nature et les technologies (FQRNT).

Publication History

  1. Issue published online: 4 JUL 2012
  2. Article first published online: 6 JUN 2012
  3. Manuscript Received: 11 APR 2012

Funded by

  • Max-Planck Society
  • AstraZeneca UK
  • Fonds québécois de la recherche sur la nature et les technologies (FQRNT)

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Keywords:

  • continuous synthesis;
  • flow chemistry;
  • nucleophilic aromatic substitution;
  • purification;
  • simulated moving-bed chromatography
Thumbnail image of graphical abstract

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module (see scheme).

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