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Keywords:

  • caged probes;
  • cobalamines;
  • fluorescent probes;
  • fluorescence spectroscopy;
  • photolysis
Thumbnail image of graphical abstract

Falling apart, on cue: Signaling pathways often display a profound spatiotemporal component that is best studied using light-activatable reagents. Three separate photolabile moieties that can be distinguished based upon their response to three distinct wavelengths (360, 440, and 560 nm) have been synthesized and evaluated. This tri-color system is also applied to imaging in microwells and HeLa cells (see picture).