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Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core–Shell Quantum Dots using Cyclooctyne Click Chemistry


  • This work was supported by the Faculty of Science, University of Melbourne, and the Australian Research Council (ARC).


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Twinkle twinkle quantum dot: Conjugation of biomolecules to azide-modified quantum dots (QDs) through a bifunctional linker, using strain-promoted azide–alkyne cycloaddition with the QD and a squaramide linkage to the biomolecule (see scheme). Transferrin-conjugated QDs were internalized by transferrin-receptor expressing HeLa cells.